BRAF Mutations in Non–Small-Cell Lung Cancer
نویسندگان
چکیده
منابع مشابه
Clinicopathological features of nonsmall cell lung carcinomas with BRAF mutations.
BACKGROUND Recently, driver tyrosine kinase gene mutations have been detected in malignant tumors, including lung tumors. Notwithstanding their attractiveness as targets for molecular therapy, limited information is available regarding BRAF-mutated lung carcinomas. MATERIALS AND METHODS BRAF mutation status was determined in 2001 surgically resected nonsmall-cell lung cancer (NSCLC) cases usi...
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OBJECTIVES Targeted therapies in non-small cell lung cancer (NSCLC) now also include inhibitors against mutated BRAF. We present clinicopathological characteristics of nearly one thousand unselected NSCLC patients tested for the targetable V600E/K BRAF-mutation. MATERIAL AND METHODS NSCLC routinely tested for EGFR-mutations at Oslo University Hospital in the period February 2011-July 2013 wer...
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BACKGROUND Previous studies investigating the association between BRAF mutations and nonsmall cell lung cancer (NSCLC) remain controversial. To address the issue, we performed an updated meta-analysis of related articles. METHODS We conducted a comprehensive literature search in the electronic databases including ISI Science Citation Index, EMBASE, PubMed, and CNKI (up to January 2016). The o...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2014
ISSN: 1556-0864
DOI: 10.1097/jto.0000000000000382